Research – Selected Publications


  1. Ghadirian. A-M.:  A tissue culture study of morphine dependence on the mammalian CNS, Canadian Psychiatric  Association Journal, 14, 607-615. 1989.
  2. Ghadirian, A-M.: Learning and insight in psychotherapy.  Confinia Psychiatrica, 19: 121-128, 1976.
  3. Ghadirian, A-M. and Lapierre, Y.D.:  Postoperative psychotic reactions. Modern Medicine of Canada, 31: 15-18, 1976.
  4. Ghadirian, A-M.:  Graphic art and its relation to conceptual thinking.  Confinia Psychiatrica, 21: 165-169, 1978.
  5. Ghadirian, A-M. and Butter, H.J.:  Sensory perception and motoric reactivity in schizophrenic patients. J. of Clinical Psychology, 34: 629-633, 1978.
  6. Chouinard, G., Ghadirian, A-M. and Jones B.:  Death attributed to ventricular arrhythmia induced by thiordazine in combination with a single contact – CR capsule.  Canadian Medical Association Journal, 199: 729-731, 1978.
  7. Ghadirian, A-M.:  Adolescent alcoholism:  Motives and alternatives.  Comprehensive Psychiatry, 20: 469-474, 1979.
  8. Mekhedova, Y.A. and Ghadirian, A.M.:  The influence of experimental neurosis on the conditional reflexes and the blood content of catecholamines and acetylcholine in dogs.  The Pavlovian Journal of Biological Science, 14: 79-85, 1979.
  9. Ananth, J. and Ghadirian, A-M.:  Drug induced mood disorders. International Pharmacopsychiatry J., 15: 59-73, 1980.
  10. Ghadirian, A-M., and Lehman, H.E.:  Neurological side effects of lithium:  Organic brain syndrome, seizures, extra-pyramidal side effects, and EEG changes.  Comprehensive Psychiatry, 21: 327-335, 1980.
  11. Ghadirian, A-M., Ananth, J. and Engelsmann, F.:  Folic acid deficiency and depression.  Psychosomatics, 21: 926-929, 1980.
  12. Ghadirian, A-M. and Lehmann, H.E.:  Acquired transient CNS hyper-sensitivity to lithium, Can. J. Psychiatry, 25: 662-665, 1980.
  13. Ananth, J., Gold, J., Ghadirian, A-M., and Engelsmann, F.:  Long term effects of lithium carbonate on cognitive functions.  Journal of Psychiatric Treatment and Evaluation, 3: 551-555, 1981.
  14. Ghadirian, A-M. and Engelsmann, F.:  Medical students’ interest and attitude towards psychiatry.  Journal of Medical Education, 56: 361-362, 1981.
  15. Ghadirian, A-M. and Engelsmann, F.:  Medical students’ interest and attitude towards psychiatry:  A ten-year comparison.  Medical Education, 16: 39-43, 1982.
  16. Ghadirian, A-M. and Engelsmann, F:  Emotional disorders among medical students.  Journal of Psychiatric Treatment and Evaluation, 4: 459-461, 1982.
  17. Ghadirian, A-M., Chouinard, G. and Annable, L.: Sexual dysfunction and plasma prolactin levels in neuroleptic treated chronic schizophrenic out-patients.  The Journal of Nervous and Mental Disease, 170: 463-467, 1982.
  18. Ramsay, R.A., Ananth, J., Engelsmann, F., Krakowski, A.J., Wittkower, E.D. and Ghadirian, A-M.,  Schizophrenia and psychosomatic illness.  Journal of Psychosomatic Research, 26: 33-42, 1982.
  19. Ghadirian, A-M., Engelsmann, and Ananth, J.:  Memory functions during lithium therapy.  Journal of Clinical Psychopharmacology, 3: 313-315, 1983.
  20. Engels, M.R., Ghadirian, A-M. and Dongier, M.:  DSM  III in Canada:  The viewpoint of academic psychiatrists.  In:  International Perspectives on DSM III (R.L. Spitzer, J.B.W. Williams and A. Skodol, Eds.), American Psychiatric Press Inc. Washington, D.C., p. 135. 1983.
  21. Yassa, R., Ghadirian, A-M. and Schwartz, G.:  Prevalence of tardive dyskinesia in affective disorder patients. J. Clin. Psychiatry, 44 (11): 410-412, 1983.
  22. Ghadirian, A-M., Lehmann, H.E., Dongier, M. and Kolivakis, T.:  Multiple personality in a case of functional psychosis.  Comprehensive Psychiatry, 26: 22-28, 1985.
  23. Engels, M.L., Ghadirian, A-M. and Dongier, M.: DSM III, The view from Canadian academe.  Psychiatric Journal of the University of Ottawa, 10 (1): 37-40, March 1985.
  24. Ghadirian, A-M. and Engelsmann, F.:  Somatic illness in manic-depressive and schizophrenic patients. Journal of Psychosomatic Research, 29: 281-286, 1985.
  25. Ghadirian, A-M., Lalinec-Michaud, M. and Engelsmann, F.:  Early and late onset of affective disorders:  Clinical and family characteristics.  Annuals of the Royal College of Physicians and Surgeons of Canada, 19: 53-57, 1986.
  26. Ghadirian, A-M., Gauthier, S. and Bertrand, S.:  Anxiety attacks in a patient with a right temporal lobe meningioma.  Journal of Clinical Psychiatry, 47: 270-271, 1986.
  27. Ghadirian, A-M. and Engelsmann, F.:  Residents’ view of psychiatric training.  Journal of Psychiatric Education, 10 (1): 31-39, 1986.
  28. Ghadirian, A-M., Subak, M.E., Kovess, V., Gregoire, G. and Prince, R.:  Alcohol and Drug Use Among Montreal High School Students.  Proceedings of the 34th International Congress on Alcoholism and Drug Dependence (1985), Volume 2, Papers, 22-24, (published in 1986).
  29. Ghadirian, A-M.:  Paradoxical mood response following anti-depressant withdrawal.  Biological Psychiatry, 21: 1298-1300, 1986.
  30. Dent, R.M.R., Ghadirian, A-M., Kusalic, M. and Young, S.:  Diurnal rhythms of plasma cortisol, beta-endorphin and prolactin, and cerebrospinal fluid amine metabolite levels before suicide:  Case report.  Neuropsychobiology, 16: 64-67, 1986.
  31. Steiger, H., Leichner, P. and Ghadirian, A-M.: Perspectives on the prevention of Anorexia Nervosa and Bulimia.  Canadian Family Physician, 33: 145-150, 1987.
  32. Ghadirian, A-M. and Kamaraju, L.S.:  Premenstrual mood changes in affective disorders.  Can. Med. Assoc. J.,  136: 1027-1032, 1987.
  33. Ananth, J., Ghadirian, A-M. and Engelsmann, F.:  Lithium and memory:  A review. Canadian J. Psychiatry, 32: 312-316, 1987.
  34. Ghadirian, A-M., Gauthier, S. and Wong, T.:  Convulsions in patints abruptly withdrawn from clonazepam while receiving neuroleptic medication.  American J. of Psychiatry,  144: 686, 1987.
  35. Ghadirian, A-M., Gauthier, S. and Wong, T.:  Clonazepam withdrawal and convulsion in psychiatric patients treated with neuroleptics.  Proceedings of the Eighth World Congress of the International College of Psychosomatic Medicine, September 3-7, 1985.  The University of Chicago, 1987, pp. 126-132.
  36. Ghadirian, A-M., Gianoulakis, C. and Nair, N.P.V.:  The effect of electroconvulsive therapy on endorphins in depression.  Biol. Psychiatry, 23: 459-464, 1988.
  37. Ghadirian, A-M., Steiger, H. and Leichner, P.:  A manic episode in the course of anorexia nervosa, Psychosomatics, 30: 101-103, 1989.
  38. Steiger, H. and Ghadirian, A-M.:  Atypical eating disorders resembling Anorexia Nervosa: A report of five cases.  Int. J Eating Disorders. 8: 307-314, 1989.
  39. Ghadirian, A-M., Nair, N.P.V. and Schwartz, G.:  Transmembrane lithium distribution and hypertension in manic-depressive patients.  Prog. Neuropsychopharmacol. & Biol. Psychiat. 13: 525-530, 1989.
  40. Ghadirian, A-M., Nair, N.P.V. and Schwartz, G.: Effect of lithium and neuroleptics in combination on lithium transport, blood pressure and weight in bipolar patients.  Biol. Psychiatry. 28: 139-144, 1989.
  41. Young, S. and Ghadirian, A-M.:  Folic Acid and Psychopathology.  Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 3: 841-863, 1989.
  42. McMillan, M., Ghadirian, A-M. and Pihl, R.:  Premenstrual depression in women with a history of affective disorders:  Mood and attentional processes.  Can. J. Psychiatry, 34: 791-795, 1989.
  43. Ghadirian, A-M. and Leichner, P.:  Psychiatric residents’ educational experiences and attitude towards eating disorders.  Can J. Psychiatry, 35:  254-256, 1990.
  44. Ghadirian, A-M., Lithium – Tricyclic antidepressant versus Lithium – MAOI combination treatment in refractory depression.  Lithium, 1 (2): 128-130, 1990.
  45. Murphy, B.E.P., Dhar, V., Ghadirian, A-M., Chouinard, G. and Keller, R.:  Response to steroid suppression in major depression resistant to antidepressant therapy,  J. Clinical Psychopharmacology, 11: 121-126, 1991.
  46. Lalinec-Michaud, M., Subak, M.E., Ghadirian, A-M. and Kovess, V.:  Substance misuse among native and rural high school students in Quebec.  The international Journal of the Addictions, 26: 1003-1012, 1991.
  47. Engelsmann, F., Ghadirian, A-M. and Grof, P.:  Lithium treatment and memory assessment:  Methodological issues.  Neuropsychobiology, 26: 113-119, 1992.
  48. Ghadirian, A-M., Annable, L. and Belanger, M.C.:  Lithium, benzodiazepines, and sexual function in bipolar patients, Am J. Psychiatry. 149: 801-805, 1992.
  49. Steiger, H., Thibaudeau, J., Ghadirian, A-M. and Houle, L.:  Psychopathological features in bulimics as a function of Axis II Comorbidity:  Isolation of mood-independent differences. International J. Eating Disorders, 12: 383-395, 1992.
  50. Murphy, B.E.P., Dhar, Ghadirian, A-M., Chouinard, G. and Keller, R.:  Theoretical basis for response to steroid suppression in major depression. (Let to Ed.) J. Clin. Psychopharmacology, 12: 143-144, 1992.
  51. Ghadirian, A-M. and Dubrovsky, B.:  A longitudinal CNV study of the evolution and treatment of bipolar illness. Intern. J. Neuroscience, 72: 245-250, 1993.
  52. Ghadirian, A-M., Engelsmann, F., Leichner, P. and Marshall, M.:  Prevalence of psychosomatic and other medical illnesses in anorexic and bulimic patients.  Behavioural Neurology, 6: 123-137, 1993.
  53. Murphy, B.E.P. Filipini, D. and Ghadirian, A-M.:  Possible use of glucosteriod antagonists in the treatment of major depression:  Preliminary results using RU 485.  J. Psychiatry & Neuroscience, 18: 209-213, 1993.
  54. Malec, T.S., Dobkin, P.L., Dongier, M. Ghadirian, A-M. and Kealey, S.:  A clinical trial of the combination of L-tryptophan and lithium in the treatment of chronic alcoholism.  Lithium, 5: 23-27, 1994.
  55. Ghadirian, A-M., Engelsmann, F., Dhar, V., Filipini, D., Keller, R., Chouinard, G. and Murphy, B.E.P.:  The psychotropic effects of steroid biosynthesis in depressed patients refractory to treatment.  Biol. Psychiatry, 37: 369-375, 1995.
  56.  Steiger, H., Stotland, S., Ghadirian, A-M. and Whitehead, V.:  Controlled study of eating concerns and psychopathological traits in relatives of eating disordered probands.  Do familial traits exist?  Int. J. Eating Disorders, 18: 107-118, 1995.
  57. Ghadirian, A-M.:  The impact of alcoholism on the family environment.  Chinese Mental Health Journal, (sup 1996): 129-130, 1996.
  58. Ghadirian, A-M.:  Bulimic purging through blood donation.  Am J Psychiatry, 154: 435-436, 1997.
  59. Leyton, M., Young, S.N., Blier, P., Ellenbogen, M., Palmour, R., Ghadirian, A-M. and Benkelfat, C.:  The effect of tryptophan depletion on mood in medication-free, former patients with major affective disorder.  Neuropsychopharmacology, 16: 294-297, 1997.
  60. Ghadirian, A-M.:  Intergenerational responses to persecutionIn International Handbook of Multigenerational Legacies of Trauma, Ed:  Danieli, Y.  Plenum Press, 1998, pp. 513-532.
  61.  Ghadirian, A-M., Murphy, B.E.P. and Gendron, M-J.:  Efficacy of light therapy versus tryptohan therapy in season affective disorder.  J. Affective Disorders, 50: 23-27, 1998.
  62. Murphy, B.E.P., Ghadirian, A-M. and Dhar, V.:  Neuroendocrine responses to inhibitors of steroid biosynthesis in patients with major depression resistant to antidepressant therapy.  Can J Psychiatry, 43: 279-286, 1998.
  63. Cervantes, P., Ghadirian, A-M. and Vida, S.:  Vitamin B12 and folate levels and lithium administration in patients with affective disorders.  Biol. Psychiatry, 45: 214-221, 1999.
  64. Ghadirian, A-M., Marini, N., Jabalpurwala, S., Steiger, H.:  Seasonal mood patterns in eating disorders. General Hospital Psychiatry, 21: 354-359, 1999.
  65. Leyton, M., Ghadirian, A-M., Young, S.N., Palmour, T.M., Blier, P., Helmers, K.F. and Benkelfat, C.:  Depressive relapse following acute tryptophan depletion in patients with major depressive disorder.  J. Psychopharmacology, 14: 284-287, 2000.
  66.  Ghadirian, A-M., Gregoire, P. and Kosmidis, H.:  Creativity and the evolution of psychopathologies. Creativity Research Journal, 13: 145-148, 2000-01.
  67.  Ghadirian, A-M., Marcovitz, S., Murphy, B.E.P.:  A case of seasonal bipolar disorder exacerbated by Cushing’s disease.  Comprehensive Psychiatry, (46) 155-158, 2005.
  68. Ghadirian, A-M.:  Is spirituality relevant to the practice of medicine?  International Journal of Medicine and Law, Vol. 27 (No.2), 2008, pp. 229-239.
  69. Ghadirian, A-M., Psychosocial factors in prevention of drug abuse and dependence, Chinese Journal of Drug Dependence, vol. 18 (6): 521-526, 2009.
  70. Ghadirian, A-M.:  An Integrated Approach to Drug-Abuse Treatment:  The Role of Prevention.  In Substance Abuse Disorders:  Evidence and Experience (Hamid Ghodse, Helen Herrman, Mario Maj, Norman Sartorius – Eds.), John Wiley & Sons Ltd., West Sussex, UK, 2001, pp. 91-94.
  71. Ghadirian, A-M.:  Spiritual Dimensions of Whole Person Care,  In:  Whole Person Care – A New Paradigm for the 21st Century (Tom A. Hutchinson, Ed.), Springer, New York, 2011, pp. 149-160.
  72. Ghadirian, A-M.: Depression:  Biological, Psychosocial and Spiritual Dimensions and Treatment.  Journal of Baha’i Studies, vol. 25, No. 4, winter 2015, pp. 25-60.